Two sample MR report
RSPH4A_Smooth Muscle Cell (SMC) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.0151947 | 0.2208035 | 0.9562596 |
| Weighted median | 3 | 0.0256787 | 0.0149040 | 0.0848999 |
| Inverse variance weighted | 3 | 0.0253105 | 0.0126599 | 0.0455801 |
| Simple mode | 3 | 0.0267309 | 0.0164606 | 0.2458760 |
| Weighted mode | 3 | 0.0265858 | 0.0169510 | 0.2573338 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0041657 | 1 | 0.9485387 |
| Inverse variance weighted | 0.0379286 | 2 | 0.9812144 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0374948 | 0.2040568 | 0.8843135 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.34e-05 | 0 | TRUE | 0.4875691 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
